Bulk Camptothecin Powder sales@optimumpowder.com

Titulo: Bulk Camptothecin Powder sales@optimumpowder.com


Website: www.optimumpowder.com
Email: sales@optimumpowder.com
Skype: optimumpowder

Quick Details:
CAS No: 7689-03-4
Molecular Formula: C20H16N2O4
Molecular Weight: 348.35
Assay: 98.62%
Appearance: Light Yellow Crystalline Powder

Camptothecin Powder Profile:
Camptothecin (CPT) is an alkaloid isolated from the the bark and stem wood of the Chinese tree, Camptotheca acuminate. CPT showed remarkable anticancer activity in preliminary clinical trials but also severe side effects, which limits its usefulness in patients. Currently, two semi-synthetic derivatives of camptothecin, topotecan and irinotecan, which retain anti-cancer activity but with less severe side effects, are used to treat a variety of cancers.

Camptothecin Powder Effects:
1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.

3. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

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